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作者:威斯尼斯人娱乐官方进入发布时间:2022年08月03日 15:01


1. Su N, Zhu A, Tao X, Ding ZJ, Chang S, Ye F, Zhang Y, Zhao C, Chen Q, Wang J, Zhou CY, Guo Y, Jiao S, Zhang S, Wen H, Ma L, Ye S, Zheng SJ, Yang F, Wu S, Guo J. (2022) Structures and mechanisms of the Arabidopsis auxin transporter PIN3. Nature doi.org/10.1038/s41586-022-05142-w

2. Feng T, Wu P, Gao H, Kosma DK, Jenks MA, Lü S. (2022) Natural variation in root suberization is associated with local environment in Arabidopsis thaliana. New Phytologist doi.org/10.1111/nph.18341

3. Wang T, Dong D, Chen T, Zhu J, Wang S, Wen W, Zhang X, Tang H, Liang J, Wang S, Xiong H. (2022) Acidity-responsive cascade nanoreactor based on metal-nanozyme and glucose oxidase combination for starving and photothermal-enhanced chemodynamic antibacterial therapy. Chemical Engineering Journal 446, 137172

4. Li H, Yang Y, Hu Y, Chen CC, Huang JW, Min J, Dai L, Guo RT. (2022) Structural analysis and engineering of aldo-keto reductase from glyphosate-resistant Echinochloa colona. Journal of Hazardous Materials 436, 129191.

5. Dong Y, Wu M, Zhang Q, Fu J, Loiacono FV, Yang Y, Wang Z, Li S, Chang L, Bock R, Zhang J. (2022) Control of a sap-sucking insect pest by plastid-mediated RNA interference. Molecular Plant 15, 1176–1191. 

6. Li Q, Zhang Z, Zhao J, Li A. (2022) Recent advances in the sustainable production of α, ω-C6 bifunctional compounds enabled by chemo-/biocatalysts. Green Chemistry 24, 4270–4303

7. Li W, Liu Y, He R, Wang L, Wang Y, Zeng W, Zhang Z, Wang F, Ma L. (2022) A programmable pAgo nuclease with RNA target preference from the psychrotolerant bacterium Mucilaginibacter paludis. Nucleic Acids Research 50, 5226–5238.

8. Zhang S, Liu, Y; Ma Y; Wang H; Zhao Y; Kuntner M, Li D. (2022) Male spiders avoid sexual cannibalism with a catapult mechanism. Current Biology 32, 354–355.

9. Qin W, Xu W, Wang L, Ren D, Cheng Y, Song W, Jiang T, Ma L, Zhang C. (2022) Bacteria-elicited specific thrombosis utilizing acid-induced cytolysin A expression to enable potent tumor therapy. Advanced Science 9, 202105086.

10. Wu M, Dong Y, Zhang Q, Li S, Chang L, Loiacono FV, Ruf S, Zhang J, Bock R. (2022) Efficient control of western flower thrips by plastid-mediated RNA interference. Proceedings of the National Academy of Sciences of the United States of America 119, e2120081119.

11. Huang J, Dai W, Xiao D, Xiong Q, Liu C, Hu J, Ge F, Yu X, Li S. (2022) Acetylation-dependent SAGA complex dimerization promotes nucleosome acetylation and gene transcription. Nature Structural & Molecular Biology 29, 261–273.

12. Li Y, Wang Y, Wang R, Yan X, Wang J, Wang X, Chen S, Bai F, He Q, Yang S. (2022) Metabolic engineering of Zymomonas mobilis for continuous co-production of bioethanol and poly-3-hydroxybutyrate (PHB). Green Chemistry 24, 2588–2601.

13. Peng Y, Gao C, Zhang Z, Wu S, Zhao J, Li A. (2022) A chemoenzymatic strategy for the synthesis of steroid drugs enabled by P450 monooxygenase-mediated steroidal core modification. ACS Catalysis 12, 2907–2914.

14. Zeng W, Li X, Yang Y, Min J, Huang JW, Liu W, Niu D, Yang X, Han X, Zhang L, Dai L, Chen CC, Guo RT. (2022) Substrate-binding mode of a thermophilic PET hydrolase and engineering the enzyme to enhance the hydrolytic efficacy. ACS Catalysis 12, 3033–3040.

15. Chen CC, Dai M, Zhang L, Zhao J, Zeng W, Shi M, Huang JW, Liu W, Guo RT, Li A. (2022) Molecular basis for a toluene monooxygenase to govern substrate selectivity. ACS Catalysis 12, 2831–2839.

16. Qi Y, Ye Y, Wang R, Yu S, Zhang Y, Lv J, Jin W, Xia S, Jiang W, Li Y, Zhang D. (2022) Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response. Redox Biology 50, 102248.

17. Mao Z, Xiao H, Shen P, Yang Y, Xue J, Yang Y, Shang Y, Zhang L, Li X, Zhang Y, Du Y, Chen CC, Guo RT, Zhang Y. (2022) KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discovery 8, 5.

18. Jiang M, Li Q, Hu S, He P, Chen Y, Cai D, Wu Y, Chen S. (2022) Enhanced aerobic denitrification performance with Bacillus licheniformis via secreting lipopeptide biosurfactant lichenysin. Chemical Engineering Journal 434, 134686.

19. Zhan Y, Shi J, Xiao Y, Zhou F, Wang H, Xu H, Li Z, Yang S, Cai D, Chen S. (2022) Multilevel metabolic engineering of Bacillus licheniformis for de novo biosynthesis of 2-phenylethanol. Metabolic Engineering 70, 43–54.

20. Li S, Yang X, Huang H, Qiao R, Jenks MA, Zhao H, Lü S. (2022) Arabidopsis ACYL-ACTIVATING ENZYME 9 (AAE9) encoding an isobutyl-CoA synthetase is a key factor connecting branched-chain amino acid catabolism with iso-branched wax biosynthesis. New Phytologist 233, 2458–2470.


1. Li Q, Di J, Liao X, Ni J, Li Q, He YC, Ma C (2021) Exploration of benign deep eutectic solvent-water systems for the highly efficient production of furfurylamine from sugarcane bagasse via chemoenzymatic cascade catalysis. Green Chemistry 23, 8154-8168.

2. Zhan Y, Xu Y, Lu X, Zhou F, Zheng P, Wang D, Cai D, Yang S, Chen S. (2021) Metabolic engineering of Bacillus licheniformis for sustainable production of isobutanol. ACS Sustainable Chemistry & Engineering 9, 51.

3. Zhou P, Wang L, Liu H, Li C, Li Z, Wang J, Tan X. (2021) CyanoOmicsDB: an integrated omics database for functional genomic analysis of cyanobacteria. Nucleic Acids Research 50, 758–764.

4. Hu YH, Wang Y, Wang F, Dong YM, Jiang WL, Wang YP, Zhong X, Ma LX. (2021) SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association. Cellular & Molecular Immunology 18, 1708–1717.

5. Wang L, Qin W, Xu W, Huang F, Xie X, Wang F, Ma L, Zhang C. (2021) Bacteria-mediated tumor therapy via photothermally-programmed cytolysin A expression. Small 17, e2102932.

6. Min J, Nwachukwu JC, Min CK, Njeri JW, Srinivasan S, Rangarajan ES, Nettles CC, Guillen VS, Ziegler Y, Yan S, Carlson KE, Hou Y, Kim SH,  Novick S, Pascal BD, Houtman R, Griffin PR, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW. (2021) Dual-mechanism estrogen receptor inhibitors. Proceedings of the National Academy of Sciences of the United States of America 118, e2101657118.

7. Chen W, Chen W, Yu X, Wu Y, Tang J, Yu Q, Lv X, Zha Z, Hu B, Li X, Chen J, Ma L, Workman JL, Li S. (2021) The SESAME complex regulates cell senescence through the generation of acetyl-CoA. Nature Metabolism 3, 983–1000.

8. Qiao B, Xu J, Yin W, Xin W, Ma L, Qiao J, Liu Y. (2021) “Aptamer-locker” DNA coupling with CRISPR/Cas12a-guided biosensing for high-efficiency melamine analysis. Biosensors and Bioelectronics 183, 113233.

9. Chen CC, Han X, Li X, Jiang P, Niu D, Ma L, Liu W, Li S, Qu Y, Hu H, Min J, Yang Y, Zhang L, Zeng W, Huang J, Dai L, Guo RT. (2021) General features to enhance enzymatic activity of poly (ethylene terephthalate) hydrolysis. Nature Catalysis 4, 425–430.

10. Xu L, Xu S, Sun L, Zhang Y, Luo J, Bock R, Zhang J. (2021). Synergistic action of the gut microbiota in environmental RNA interference in a leaf beetle. Microbiome 9, 1–14.

11. Jia Y, Jin S, Hu K, Geng L, Han C, Kang R, Pang Y, Ling E, Tan EK, Pan Y, Liu W. (2021) Gut microbiome modulates Drosophila aggression through octopamine signaling. Nature Communications 12, 1–12.

12. Zhang S, Yu X, Zhang Y, Xue X, Yu Q, Zha Z, Gogol M, Workman JL, Li, S. (2021). Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation. Nature Communications 12, 1–15.

13. Wang F, Yang J, He R, Yu X, Chen S, Liu Y, Wang L, Li A, Liu L, Zhai C, Ma L. (2021) PfAgo-based detection of SARS-CoV-2. Biosensors and Bioelectronics 177, 112932.

14. Liu Y, Li, W, Jiang X, Wang Y, Zhang Z, Liu Q, He R, Chen Q, Yang J, Wang L, Wang F, Ma L. (2021) A programmable omnipotent Argonaute nuclease from mesophilic bacteria Kurthia massiliensis. Nucleic Acids Research 49, 1597–1608.


1. Chen CC, Dai L, Ma L, Guo RT. (2020). Enzymatic degradation of plant biomass and synthetic polymers. Nature Reviews Chemistry 4 114–126.

2. Ouyang M, Li X, Zhang J, Feng P, Pu H, Kong L, Bai Z, Rong L, Xu X, Chi W, Wang Q, Chen F, Lu C, Shen J, Zhang L. (2020) Liquid-liquid phase transition drives intra-chloroplast cargo sorting. Cell 180, 1144–1159.

3. Chen CC, Zhang L, Yu X, Ma L, Ko T P, Guo RT. (2020). Versatile cis-isoprenyl diphosphate synthase superfamily members in catalyzing carbon-carbon bond formation. ACS Catalysis 10, 4717–4725.

4. Chen CC, Malwal SR, Han X, Liu W, Ma L, Zhai C, Dai L, Huang JW, Shillo, A, Desai J, Ma X, Zhang Y, Guo RT, Oldfield, E. (2020) Terpene cyclases and prenyltransferases: structures and mechanisms of action. ACS Catalysis 11, 290–303.

5. Wang F, Zhao J, Li Q, Yang J, Li R, Min J, Yu X, Zheng GW, Yu HL, Zhai C, Acevedo-Rocha CG, Ma L, Li A. (2020) One-pot biocatalytic route from cycloalkanes to α, ω‐dicarboxylic acids by designed Escherichia coli consortia. Nature Communications 11, 1–10.

6. Zhang L, Xie Z, Liu Z, Zhou S, Ma L, Liu W, Huang J W, Ko TP, Li X, Hu Y, Min J, Yu X, Guo RT, Chen CC. (2020) Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase. Nature Communications 11, 2676.

7. Zhang Z, Li Q, Wang F, Li R, Yu X, Kang L, Zhao J, Li, A. (2020) One-pot biosynthesis of 1, 6-hexanediol from cyclohexane by de novo designed cascade biocatalysis. Green Chemistry 22, 7476–7483.

8. Chen CC, Zhang L, Yu X, Ma L, Ko TP, Guo RT. (2020) Versatile cis-isoprenyl diphosphate synthase superfamily members in catalyzing carbon-carbon bond formation. ACS Catalysis 10, 4717–4725.

9. Li A, Acevedo‐Rocha CG, D'Amore L, Chen J, Peng Y, Garcia‐Borràs M, Gao C, Zhu J, Rickerby H, Osuna S, Zhou J, Reetz MT. (2020). Regio‐and stereoselective steroid hydroxylation at C7 by cytochrome P450 monooxygenase mutants. Angewandte Chemie International Edition 59, 12499–12505.

10. Zhang C, Qin WJ, Bai XF, Zhang XZ. (2020). Nanomaterials to relieve tumor hypoxia for enhanced photodynamic therapy. Nano Today 35, 100960.

11. Qu G, Li A, Acevedo‐Rocha CG, Sun Z, Reetz MT. (2020) The crucial role of methodology development in directed evolution of selective enzymes. Angewandte Chemie International Edition 59, 13204–13231.


1. Li A, Qu G, Sun Z, Reetz MT. (2019) Statistical analysis of the benefits of focused saturation mutagenesis in directed evolution based on reduced amino acid alphabets. ACS Catalysis 9, 7769–7778.

2. Yang Y, Li L, Yuan L, Zhou X, Duan J, Xiao H, Cai N, Han S, Ma X, Liu W, Chen CC, Wang L, Li X, Chen J, Kang N, Chen J, Shen Z., Malwal S R, Liu W, Shi Y, Oldfield E, Guo RT, Zhang Y. (2019) A structural change in butyrophilin upon phosphoantigen binding underlies phosphoantigen-mediated Vγ9Vδ2 T cell activation. Immunity 50, 1043–1053

3. Li RJ, Li, LM, Liu XL, Kim JC, Jenks M A, Lü S. (2019). Diurnal regulation of plant epidermal wax synthesis through antagonistic roles of the transcription factors SPL9 and DEWAX. The Plant Cell 31, 2711–2733.

4. Fan W, Lu J, Pan C, Tan M, Lin Q, Liu W, Li D, Wang L, Hu L, Wang L, Chen C, Wu A, Yu X, Ruan J, Yu J, Hu S, Yan X, Lü S, Cui P. (2019). Sequencing of Chinese castor lines reveals genetic signatures of selection and yield-associated loci. Nature Communications 10, 1–11.

5. Lu Z, Yang, S, Yuan, X, Shi Y, Ouyang, L, Jiang S, Yi L, Zhang, G. (2019). CRISPR-assisted multi-dimensional regulation for fine-tuning gene expression in Bacillus subtilis. Nucleic Acids Research 47, e40.

6. Mei Q, Xu C, Gogol M, Tang J, Chen W, Yu X, Workman JL, Li S. (2019). Set1-catalyzed H3K4 trimethylation antagonizes the HIR/Asf1/Rtt106 repressor complex to promote histone gene expression and chronological life span. Nucleic Acids Research 47, 3434–3449.

7. Ma R, Wu Y, Zhai Y, Hu B, Ma W, Yang W, Yu Q, Chen Z, Workman JL, Yu X, Li S. (2019) Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway. Nucleic Acids Research 47, 11132–11150.

8. Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Amy E. Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK. (2019) Insights into the pathogenesis of catecholaminergic polymorphic ventricular tachycardia from engineered human heart tissue. Circulation 140, 390–404.

9. Xia J, Yang Y, Liu CG, Yang S, Bai FW. (2019) Engineering Zymomonas mobilis for robust cellulosic ethanol production. Trends in Biotechnology 37, 960–972.

10. Peng B, Ma CL, Zhang PQ, Wu CQ, Wang ZW, Li AT, ... & Yang B. (2019). An effective hybrid strategy for converting rice straw to furoic acid by tandem catalysis via Sn-sepiolite combined with recombinant E. coli whole cells harboring horse liver alcohol dehydrogenase. Green Chemistry 21, 5914–5923.

11. Zheng Y, Han J, Wang B, Hu X, Li, R, Shen W, ... & Peng W. (2019). Characterization and repurposing of the endogenous Type IF CRISPR-Cas system of Zymomonas mobilis for genome engineering. Nucleic Acids Research 47, 11461–11475.

12. Chen CC, Hu X, Tang X, Yang Y, Ko T P, Gao J, ... & Guo RT. (2018) The crystal structure of a class of cyclases that catalyze the cope rearrangement. Angewandte Chemie International Edition 130, 15280–15284.

13. Zhou H, Wang B, Wang, F, Yu X, Ma L, Li A, Reetz MT. (2019) Chemo‐and regioselective dihydroxylation of benzene to hydroquinone enabled by engineered cytochrome P450 monooxygenase. Angewandte Chemie International Edition 131, 774–778.


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